The Duke of York relinquishes his honor as the Duke.
The royal is giving up his honors, among them the Duke of York, he has stated in a individual message.
He has been under increasing attention over his links with sex offender the financier, with requests for the royal household to take measures against him.
That now seems to have led to the royal deciding to voluntarily return his honors and to relinquish participation of the Garter Order.
In his announcement he said he continued to "vigorously deny the accusations against me".
"In consultation with the King, and my close and extended family, we have decided the persistent allegations about me distract from the duties of His Majesty and the Royal Family," said a announcement from Prince Andrew.
"I have opted, as I always have, to put my responsibility to my kin and land first.
"I stand by my decision five years ago to step back from royal engagements.
"With His Majesty's approval, we feel I must now go a further step. I will therefore no longer employ my title or the awards which have been granted to me. As I have said before, I vigorously deny the accusations against me."
Prince Andrew has faced a series of issues, such as a court case he ended with Virginia Giuffre, inquiries about his economic affairs and his involvement with an suspected intelligence operative.
He will remain a royal - but will stop to be the the Duke, a honor received from his the late Queen, the former monarch.
Andrew had already ceased to be a "working royal" and had given up the use of his HRH title and no longer appeared at public engagements. His position now will be even more reduced.
His ex-wife will be known as Sarah and no longer Duchess of York, but their children will persist to have the designation of princess.
He has been under intense scrutiny over his links with disgraced financier Jeffrey Epstein, more in recent times involving questions about when he had really ended contact.
In his BBC Newsnight interview, he had said that he had cut off all ties with Jeffrey Epstein after they had been photographed together in New York in late 2010.
But emails sent in February 2011 later emerged implying that he had in private stayed in communication with him, for example sending a message: "Keep in close touch and we'll meet again soon!"
There had been growing frustration in the royal household at the scandals that remained to envelop the royal.
Next week a book released after death by Giuffre will be published which is anticipated to draw additional attention on the royal's connection with Ms Giuffre and the financier.